In this video, Dr. Tracey Marks provides an update on ketamine's use in treating depression, focusing on its mechanism as an NMDA receptor antagonist and role in neuroplasticity. She discusses the FDA approval of Spravato, a ketamine nasal spray, and compares its effectiveness with quetiapine. The video also explores the emerging role of ketamine injections and the continued success of intravenous ketamine, highlighting their potential in mental health treatment, especially for treatment-resistant depression.

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References
Reif A, Bitter I, Buyze J, et al. Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression. N Engl J Med. 2023;389(14):1298-1309. doi:10.1056/NEJMoa2304145

Loo C, Glozier N, Barton D, et al. Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial. The British Journal of Psychiatry. 2023;223(6):533-541. doi:10.1192/bjp.2023.79


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