Collagen. It’s a protein. And a pretty cool one at that. Due to it’s structure it possesses many functions within the body that exploits it’s strength, firmness, and elasticity. Collagen is found in your skin, cartilage, tendons, ligaments, blood vessels, eyes, and well, many parts of the body as collagen is one of the most abundant proteins in the body. And along with it’s abundance in our bodies, there is a growing abundance of research papers on collagen - one of which we’ll discuss today; a new collagen replacement therapy that was applied to the skin of mice and improved long-term treatment of photoaged skin. So, first we’ll look in more detail at both the structure of collagen and where it is found in the skin. then i’ll show there method of collagen delivery and the data they present showing whether it worked, then we’ll have a discussion.

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TIMESTAMPS
Intro - 00:00
Collagen & Skin - 00:50
Restore skin? EVs vs. LNPs - 02:55
Discussion - 08:15

References
You, Y., Tian, Y., Yang, Z. et al. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nat. Biomed. Eng (2023). https://doi.org/10.1038/s41551-022-00...
Yang, Z., Shi, J., Xie, J. et al. Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. Nat Biomed Eng 4, 69–83 (2020). https://doi.org/10.1038/s41551-019-04...
The Extracellular Matrix in Skin Inflammation and Infection - https://doi.org/10.3389/fcell.2021.68...

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

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