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The R-Files episode 1:    • An introduction to the study of RAPAM...  
The R-Files episode 2:    • Off-Label Rapamycin Experiences & Dos...  
The R-Files episode 3:    • Rapamycin's possible SIDE EFFECTS & B...  
The R-Files episode 4:    • Rapamycin's SURPRISING Effects on Age...  

You asked, we listened. Ever since the February 2024 launch of our series "The R-Files", a series of episodes about all things rapamycin, we've received a ton of questions about this compound and how it works in the context of aging and longevity. We went through every comment you left on Youtube, Twitter, and LinkedIn to compile a list of your questions about combining interventions, optimizing rapamycin dosing, limitations in applying findings from mice and medical studies to off-label human usage of rapamycin and other supplements, and so much more.

Keep the questions coming—if there are more, we'll address them in a future AMA episode.

0:00 Trailer
0:48 Introduction
2:00 Is rapamycin a caloric restriction mimic?
6:02 In the NIH ITP studies, was there a difference in cancer mortality rates between the controls and rapamycin cohorts?
8:00 Which life extension techniques complement each other?
11:15 What does Matt think of metformin + rapamycin?
13:53 Why does Matt cycle rapamycin?
16:06 Does 1mg of rapamycin 2x per week do anything at all?
18:25 What do canker sores say about whether rapamycin is working or not?
21:59 Does Matt's knowledge that he is a quick rapamycin metabolizer change how he approaches dosing or any other aspects of taking rapamycin?
23:13 Which tests are most useful for measuring rapamycin's effects on the body?
25:14 What can we learn about health- or lifespan from people who have used rapamycin in the context of organ transplants?
27:50 How was vaccination status accounted for in COVID-19 data that Matt had previously presented?
28:30 Are there symptoms indicating mTORC2 rather than mTORC1 inhibition?
33:35 How much rapamycin per week is too much?
35:28 How many people take rapamycin off-label for longevity purposes?
36:18 Are pharmaceutical companies and/or insurance companies showing interest in off-label rapamycin use?
38:02 Will Matt run for president and make rapamycin readily available to everyone for free?

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

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https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!