During this episode of Longevity by Design, Dr. Joan Mannick explains how mTOR influences the aging process. She explains that this evolutionarily conserved protein is involved in several cellular functions in the body and acts on longevity-promoting pathways like autophagy. Dr. Mannick also discusses the connection between mTOR and the immune system, sharing her research on how low-dose mTOR inhibitors can upregulate antiviral immunity, creating an opportunity for more targeted vaccines for older adults. After extensive research on mTOR across many species, Dr. Mannick shares impressive insight into how mTOR inhibitors like rapamycin can promote longevity. Tune in to learn more about the latest research in the field.

Intro: (00:00-1:20)
Dr. Mannick’s background (1:20-6:52)
What is mTOR → (6:53–10:15)
How Rapamycin acts on mTOR → (10:16–15:17)
When to treat with Rapamycin → (15:17–21:36)
Dr. Mannick’s trials with rapalogs → (21:37–28:42)
The future of Rapamycin → (28:42–31:02)
Cautions of anti-aging therapies → (31:02–41:10)
Top tip for healthspan → (41:10–41:45)
Closing remarks (41:45–end)

To learn more: https://hubs.li/Q01CQ86r0
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