The elimination half-life of a drug is a pharmacokinetic parameter that is defined as the time it takes for the concentration of the drug in the plasma or the total amount in the body to be reduced by 50%. In other words, after one half-life, the concentration of the drug in the body will be half of the starting dose.
There are two factors that affect the elimination half-life of a drug: clearance and volume of distribution. The clearance of the drug (CL) refers to the rate at which the body eliminates the drug from the body. The volume of distribution (Vd) refers to the distribution of the drug around the body. The relationship between these factors is as follows:

t(½) = l0.693/ k

t(½)= 0.693*(Vd/CL)

The elimination half-life for ranitidine is approximately 2 hours. What percentage of this drug would be eliminated from the body 4 hours after an intravenous (IV) bolus dose?
a) 12.5 % b) 25% c) 50% d) 75% e) 87.5%

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