In this video I'll demonstrate a question I hear quite a bit:
"Should I run the distortion into the effects loop?"
"Should I use the pedal as the preamp and run it into the return, or use it like a regular pedal in the loop, using the amp's preamp?"

Tl;dw version is that it's two different sounds, but both can sound good. I actually preferred using it as the preamp with the Orange personally.

Impulse Responses used were from Celestion, amp sound taken with a Two Notes Captor into the DAW.