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Non-isolated is used in 95% of cases. "Isolated" refers to if you have two chassis that are isolated from each other, such as with a trailer and tow vehicle. Isolated is not "better" and oftentimes unnecessarily complicates your circuitry. If for some reason you do get an isolated charger (and front/rear systems are on the same chassis), you can connect both grounds to the vehicle chassis (usually via the rear system negative bus bar) and it will work the same as a non-isolated charger.

Also beware that Renogy's combined MPPT / DC-DC Combo units will max out at their listed amperage of 30A or 50A, depending on unit. So if you're driving, the unit will get 50 amps from the alternator and your solar will not add to that. For this reason I recommend getting separate solar and alternator chargers. That way you max out both solar and alternator, get all you can from each, and this translates to shorter charging times. In off-grid scenarios you need all you can get from limited sun and drive time.