Professor Andrew Gelman (Professor of Statistics at Columbia University) and I discuss the recent I-TECH clinical trial on Ivermectin for Covid-19. Ivermectin has not been found to be effective for prevention or treatment of Covid-19. Prof Gelman and I discuss issues in clinical trials and their interpretation.

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▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
0:00 Introduction
1:03 The I-TECH trial out of Malaysia
5:55 First thoughts on meta-analysis
8:03 Large effects, small effects, and the power of clinical trials
10:21 "The penicillin model" in scientific pursuit
13:39 Secondary outcomes in the I-TECH study
15:13 Why not just consider death?
17:37 Selection and publication bias are complicated in social and medical science.
24:06 Selection bias and other issues in meta-analysis of ivermectin studies.
31:11 The garden of forking paths and researcher degrees of freedom

▬ Disclaimers ▬▬▬▬▬▬▬▬▬▬

This video is for educational purposes only.

I have no conflicts of interest. I do not receive any compensation or support from any company making or developing Covid-19 vaccines or novel therapies. I made this video on my own time and with my own money and equipment, with no incentives or sponsorship (though you can buy me a coffee).

▬ About Andrew Gelman ▬▬▬▬▬▬▬▬▬▬

- Andrew's Author page at Amazon https://amzn.to/34bkHnK
- Department page at Columbia http://www.stat.columbia.edu/~gelman/
- Wikipedia https://en.wikipedia.org/wiki/Andrew_...
- Google Scholar https://scholar.google.com/citations?...
- Blog https://statmodeling.stat.columbia.edu/

▬ About this channel ▬▬▬▬▬▬▬▬▬▬

I'm Greg Tucker-Kellogg, PhD, a biology professor in Singapore with a career spanning both biotechnology and academia. Videos on this educational channel cover some of my scientific and teaching interests in genomics, bioinformatics, and biochemistry, as well as topics in current scientific issues of public interest. Links to my professional profile are available in the "about" section of the channel.

▬ References ▬▬▬▬▬▬▬▬▬▬

- Gelman A, Carlin J. Beyond Power Calculations: Assessing Type S (Sign) and Type M (Magnitude) Errors. Perspectives on Psychological Science. 2014;9(6):641-651. doi:10.1177/1745691614551642

- Lim SCL, Hor CP, Tay KH, et al. Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial. JAMA Internal Medicine. Published online February 18, 2022.https://doi.org/10.1001/jamainternmed...

- Tushar VS Sample Size Estimation in Clinical Trial Perspect Clin Res. 2010 Apr-Jun; 1(2): 67–69.
https://www.ncbi.nlm.nih.gov/labs/pmc...