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Cited articles

The four hypothesis and their conclusion

Noda-Garcia, L., Liebermeister, W., & Tawfik, D. S. (2018). Metabolite–enzyme coevolution: from single enzymes to metabolic pathways and networks. Annual Review of Biochemistry, 87, 187-216.

Protein evolution experiment

Campbell, E. C., Correy, G. J., Mabbitt, P. D., Buckle, A. M., Tokuriki, N., & Jackson, C. J. (2018). Laboratory evolution of protein conformational dynamics. Current opinion in structural biology, 50, 49-57.

Campbell, E., Kaltenbach, M., Correy, G. J., Carr, P. D., Porebski, B. T., Livingstone, E. K., Tokuriki, N., ... & Jackson, C. J. (2016). The role of protein dynamics in the evolution of new enzyme function. Nature chemical biology, 12(11), 944-950.

PDB files: 4PCP, 4PCN, 1G03, and all of http://pdb101.rcsb.org/motm/154

3D animation library created by @BradyJohnston big thanks!