A popular instructor, Sheen wrote the first of 73 books in 1925, and in 1930 began a weekly NBC Sunday night radio broadcast, The Catholic Hour.[20] Sheen called World War II not only a political struggle, but also a "theological one". He referred to Hitler as an example of the "Anti-Christ."[21] Two decades later, the broadcast had a weekly listening audience of four million people. Time referred to him in 1946 as "the golden-voiced Msgr. Fulton J. Sheen, U.S. Catholicism's famed proselytizer", and reported that his radio broadcast received 3,000–6,000 letters weekly from listeners.[22] During the middle of this era, he conducted the first religious service broadcast on the new medium of television, putting in motion a new avenue for his religious pursuits.
Television
Sheen had a radio and television program called Life Is Worth Living, which aired from 1952 to 1957.
While at Catholic University of America, Sheen celebrated an Easter Sunday Mass in 1940 that was one of the first televised religious services. During the sermon, telecast on experimental station W2XBS, Sheen remarked "this is the first religious television in the history of the world. Let therefore its first message be a tribute of thanks to God for giving the minds of our day the inspiration to unravel the secrets of the universe."[23]

On February 12, 1952, he began a weekly television program on the DuMont Television Network, titled Life Is Worth Living.[24] Filmed at the Adelphi Theatre in New York City, the program consisted of the unpaid Sheen simply speaking in front of a live audience without a script or cue cards, occasionally using a chalkboard.

The show, scheduled in a prime time slot on Tuesday nights at 8:00 p.m., was not expected to challenge the ratings giants Milton Berle and Frank Sinatra, but did surprisingly well. Berle, known to many early television viewers as "Uncle Miltie" and for using ancient vaudeville material, joked about Sheen, "He uses old material, too", and observed that "[i]f I'm going to be eased off the top by anyone, it's better that I lose to the One for whom Bishop Sheen is speaking."[10] Sheen responded in jest that maybe people should start calling him "Uncle Fultie".[25] Life and Time magazine ran feature stories on Bishop Sheen. The number of stations carrying Life Is Worth Living jumped from three to fifteen in less than two months. There was fan mail that flowed in at a rate of 8,500 letters per week. There were four times as many requests for tickets as could be fulfilled. Admiral, the sponsor, paid the production costs in return for a one-minute commercial at the opening of the show and another minute at the close.[26] In 1952 Sheen won an Emmy Award for his efforts,[27] accepting the acknowledgment by saying, "I feel it is time I pay tribute to my four writers – Matthew, Mark, Luke and John." When Sheen won the Emmy, Berle quipped, "We both work for 'Sky Chief'", a reference to Berle's sponsor Texaco. Time called him "the first 'televangelist'", and the Archdiocese of New York could not meet the demand for tickets.[10]

One of his best-remembered presentations came in February 1953, when he forcefully denounced the Soviet regime of Joseph Stalin. Sheen gave a dramatic reading of the burial scene from Shakespeare's Julius Caesar, substituting the names of prominent Soviet leaders Stalin, Lavrenty Beria, Georgy Malenkov, and Andrey Vyshinsky for the original Caesar, Cassius, Marc Antony, and Brutus. He concluded by saying, "Stalin must one day meet his judgment." The dictator suffered a stroke a few days later and died within a week.[28]

The show ran until 1957, drawing as many as 30 million people on a weekly basis. In 1958, Sheen became national director of the Society for the Propagation of the Faith, serving for eight years before being appointed Bishop of the Diocese of Rochester, New York, on October 26, 1966. He also hosted a nationally syndicated series, The Fulton Sheen Program, from 1961 to 1968 (first in black and white and then in color). The format of this series was essentially the same as Life Is Worth Living.

International cassette tape ministry
In September 1974, the Archbishop of Washington asked Sheen to be the speaker for a retreat for diocesan priests at the Loyola Retreat House in Faulkner, Maryland. This was recorded on reel-to-reel tape, state of the art at the time.[29]

Sheen requested that the recorded talks be produced for distribution. This was the first production of what would become a worldwide cassette tape ministry called Ministr-O-Media, a nonprofit company that operated on the grounds of St. Joseph's Parish, Pomfret, Maryland. The retreat album was titled, Renewal and Reconciliation, and included nine 60-minute audio tapes.