Christina Applegate has been making us laugh for decades, but tragedy followed this star from an early age. Between tragic family deaths and recurring health issues, Applegate's rise to the top of Hollywood is even more amazing.

#Actor #Celeb #Comedian

Working childhood | 0:00
Mother's cancer | 1:16
Grandmother's death | 2:06
Devastating injury | 3:12
Boyfriend's death | 4:16
Stalking and death threats | 5:03
Health scares | 6:03
Cancer challenges | 7:23
Multiple sclerosis | 8:30
Forced into retirement | 9:47

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