Kaposi sarcoma-associated herpesvirus (KSHV) is a human herpesviruses that is known to cause several diseases, including Kaposi sarcoma, primary effusion lymphoma, and AIDS-related multicentric Castleman disease. KSHV establishes a latent infection in the cell nucleus, but where KSHV episomal genomes are tethered and the mechanisms underlying KSHV lytic reactivation are unclear.

During this webinar, Dr. Yoshihiro Izumiya will share how his lab used Capture Hi-C to identify KSHV episome tethering sites on host chromosomes and characterize the surrounding nuclear microenvironment of KSHV episomes.