The Neuro-Developmental Treatment (NDT) frame of reference is used to analyze and treat posture and movement impairments based on kinesiology and biomechanics. To identify difficulties and plan for intervention, the following concepts are to be considered in NDT, including planes of movement, alignment, range of motion, base of support, muscle strength, postural control, weight shifts, and mobility. NDT assumes that posture and movement impairments are changeable. Thus, it utilizes movement analysis to identify missing or atypical elements. By treating problems of motor coordination, neuromotor and postural control abnormalities, the ultimate goal of NDT is to optimize participation in a person’s life roles. In the evaluation using NDT, each individual is evaluated as a unique person with particular competencies and limitations. Since NDT emphasizes informal, ongoing examinations as part of treatment to evaluate the treatment strategies, there are no standardized assessment formats. As for the intervention, therapeutic handling is the primary technique of NDT, with graded application of manual forces to the client’s body through the therapist’s hand, combined with directional cues for the client to feel and learn new movement patterns. Occupational therapists are often specifically involved in the facilitation of upper extremity movements such as reaching, grasping, releasing of objects, and in-hand manipulation skills. Therapeutic handling can be also embedded in functional tasks such as self-care or play. Often these functional tasks are entrenched in NDT together with other components including cognition, perception, creativity, and self-esteem.