Throughout the years, heroin users have turned to alternative opioids like fentanyl to maintain their addiction or achieve even greater highs, resulting in significantly elevated mortality rates. The switch to these new drugs is often the result of changes or disruptions in the supply of heroin. The ease of replacement has allowed suppliers to sell a product that mimics the depressant effects of even the purist heroin. Since fentanyl and its analogs can be up to 100 times more potent than heroin, the safety of officers handling buys and seizures and chemists handling submitted evidence is a significant concern to the law enforcement community. At this seminar, I will discuss the challenge in analyzing these increasingly complex drug exhibits.