Published On Oct 14, 2021
Fact checked video by FB, A video about my video about this research paper
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model
Leo Nicolai, Cardiology Fellow, Ludwig Maximilian University of Munich:
German Centre for Cardiovascular Research
Indeed, there is peer-reviewed work showing in mice that possibly intravenous injection of mRNA vaccine leads to myocardial inflammation.
that intravenous injection of adenoviral vector based vaccine (AZ1222, ChAdOx1) leads to thrombocytopenia and platelet-directed immune responses,
offering a possible explanation for vaccine-induced thrombosis/thrombocytopenia
these data might indicate a simple measure to lower the incidence of vaccine-induced side effects,
There is a lack of data on frequency and effects of IV injection in humans.
Most likely, two approaches are needed to further validate the data:
Large animal studies
Studies comparing incidence of vaccine-associated thrombosis/thrombocytopenia/ myocarditis in countries with mandated syringe aspiration to countries that don’t mandate this practice.
Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration (29th June 2021)
Recently a rare and novel complication of SARS-CoV-2 targeted adenovirus vaccines has emerged: thrombosis with thrombocytopenia syndrome (TTS).
we employ in vitro and in vivo models
to characterize the possible mechanisms of this platelet-targeted autoimmunity.
We show that intravenous but not intramuscular injection of ChAdOx1 triggers platelet-adenovirus aggregate formation and platelet activation.
After intravenous injection, these aggregates are phagocytosed by macrophages in the spleen and platelet remnants are found in the spleen.
This is followed by a pronounced B-cell response with the emergence of circulating antibodies binding to platelets.
Our work contributes to the understanding of TTS and highlights accidental intravenous injection as potential mechanism for post-vaccination TTS.
Hence, safe intramuscular injection, with aspiration prior to injection,
could be a potential preventive measure when administering adenovirus-based vaccines.
Helen Petousis-Harris, Associate Professor, University of Auckland:
Vaccinologist and associate professor at the University of Auckland
There are a range of injection techniques for administering vaccines,
Injecting fast and withdrawing the needle
Injecting slowly before withdrawing
Pulling back on the plunger, seeing there is no blood, then injecting. This is called aspiration.
Rationale for aspirating
vaccine could be inadvertently delivered into the blood rather than the muscle tissue.
But as the flashback of blood hardly ever happens, the practice was abandoned by many practitioners.
I have not seen any evidence to support the rejection of this hypothesis at this stage.
The animal model study supports the possibility that inadvertent injection into a blood vessel could result in undesirable reactions.
However, the majority of myocarditis cases are occurring in young males after the second dose, something that this hypothesis does not explain.
My conclusion is that this requires more research and observing the patterns of post-vaccine myocarditis among populations where aspiration is practiced could be helpful.
Common sense in Denmark
COVID-19 Vaccine Janssen
A single 0.5 mL dose of undiluted vaccine is given.
Based on a precautionary principle, we recommend aspiration before injection.
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