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Clinicians have the ability to eliminate cervical cancer thanks to improved screening and the HPV vaccine. At the same time, mortality rates in our mostly-rural state are roughly the same as they were in 1999. Isabel Scarinci, vice chair of global and rural health, introduces Operation Wipeout, a UAB-led plan that mobilizes civil society groups to encourage screening and vaccination across Alabama. Dr. Huh and Scarinci also discuss the hope that self-sampling for HPV screening could offer for women in rural areas who may not be able to travel to a clinic.