Nerve agents are completely terrifying - in this episode I discuss the different classes of nerve agents, and we determine which ones are the most EVIL.

Exposure to nerve agents is usually treated with atropine and pralidoxime chloride (2-PAM chloride).

Nerve agents inhibit acetylcholinesterase, which is an enzyme that catalyzes the breakdown of acetylcholine. Some nerve agents covalently bind to the enzyme, and can damage the active site of the enzyme, so the acetylcholine builds up, the signal keeps sending, and the motor neurons keep firing. The G series and V series of nerve agents were mass produced, weaponized agents, while the EA series, A series, and others are not known to be mass produced or weaponized.

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References:
(Graphic) Rabbits exposed to nerve agents -    • US Army Nerve Agent Weapons Experimen...  
Scary book - Jared Ledgard, A Laboratory History of Chemical Warfare Agents - (the link to this book was deactivated; perhaps the uploader had violated the hosting site's TOS - its ISBN-13 number is‎ 978-0615136455)
Methyl cyclosarin treatment patent - https://patents.google.com/patent/US1...
Earliest Methyl cyclosarin reference - https://sci-hub.se/10.1007/BF00354767
Previous Tierlist -    • 'Fukinone' got this tierlist demonetized  
Hydrolysis of VX/EA-2192 - https://doi.org/10.1289/ehp.99107933
VR 'first Novichok' - https://cen.acs.org/articles/96/i12/N...
SL-599 (SB-8) paper - https://pubs.acs.org/doi/10.1021/ja01...
Perfect 10 patent - https://patents.google.com/patent/US4...
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Molecules for this tierlist - Tabun (GA), Sarin (GB), Chlorosarin, Thiosarin (GBS), Soman (GD), Cyclosarin (GF), Methyl cyclosarin (EA-1356), VX, EA-2192, Russian VX (VR), Chinese VX, V-sub x, A-230, A-234, A-242, C01-A039, C01-A042, Neostigmine, TMTFA, TL-599 (SB-8), T-1123, T-1152, 4-692-530-01, 4-686-293-01 (Agent 1-10), 4-686-293-02 (Agent 1-8)

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