Gibberelins play a critical role for plants and mankind being vital factors for plant growth and agriculture. They are the reason why we avoided a global hunger wave in the 20th century, and their analogs could open new mechanisms of action against cancer! This makes synthetic access and further biochemical and pharmacological studies even more important.

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01:27 Gibberelin's role in nature and agriculture
04:38 Isolation of natural products
06:54 Retrosynthetic analysis and strategy
09:02 Forward synthesis and mechanisms

Main paper: Concise Synthesis of (−)-GA18 Methyl Ester (Lei Li, Weida Liang, Mario E. Rivera, Ye-Cheng Wang, and Mingji Dai); https://doi.org/10.1021/jacs.2c12470

Some recommended books on organic synthesis:
- Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
- Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
- Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
- Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy)
- Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
- Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)