Mortal Kombat vs. DC Universe is a 2008 fighting video game developed and published by Midway Games for the PlayStation 3 and Xbox 360. The game is a crossover between Mortal Kombat and the DC Universe, and is the eighth main installment in the Mortal Kombat franchise. The game was released on November 16, 2008.

Mortal Kombat vs. DC Universe was developed using Epic Games' Unreal Engine 3, and was the first Mortal Kombat title developed solely for the seventh generation of video game consoles. Its story was written by comic writers Jimmy Palmiotti and Justin Gray. The game was the final entry in the franchise developed by Midway Games before the company went bankrupt in 2009 and sold the franchise to Warner Bros. Interactive Entertainment.

The game's story takes place after Raiden, Earthrealm's god of thunder, and Superman, Metropolis' defender, repel invasions from both their worlds. An attack by both Raiden and Superman simultaneously in their separate universes causes the merging of the Mortal Kombat and DC villains, Shao Kahn and Darkseid, resulting in the creation of Dark Kahn, whose mere existence causes the two universes to begin merging; if allowed to continue, it would result in the destruction of both. Characters from both universes begin to fluctuate in power, becoming stronger or weaker.