In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

#DavidSinclair #Longevity #SkinCare

Thank you to our sponsors:
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Levels - https://levels.link/sinclair
InsideTracker - https://insidetracker.com/sinclair

Our Patreon page:
  / davidsinclair  

Lifespan book:
https://amzn.to/3sUqurT

Lifespan podcast website: https://www.lifespanpodcast.com

Dr. David Sinclair Social:
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Twitter -   / davidasinclair  
Facebook -   / davidsinclairphd  

Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com

Matthew LaPlante's Social:
Twitter -   / mdlaplante  

Timestamps:
00:00:00 Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair
00:02:54 Estrogen, Progesterone, and Menopause
00:09:51 Thanking the Sponsors
00:12:57 The Pinch Test, Epidermal Thinning, and Foot Ulcers
00:18:29 Skin and Biological Aging
00:23:19 Cellular Senescence, Ultraviolet Light, and Skin Aging
00:28:15 Collagen, Keratin, and Skin Health
00:33:38 A Quick Aside about Nails
00:34:45 Autophagy and Retinoids
00:36:57 Resveratrol, NAD Boosters, and Hyaluronic Acid
00:41:44 Botox, Skin Peels, and Microneedling
00:43:28 No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food
00:45:42 Hair Loss and Hair Graying
00:49:45 Topical Treatments, Pills, and Dihydrotestosterone
00:55:19 Frickin Laser Beams: Low-level Laser Therapy
00:57:59 Platelet-rich Plasma (PRP) Injections
01:00:11 Hair Aging, Stress, and Gray Hair Reversal
01:06:11 Targeting Aging Upstream
01:07:37 Today’s Takeaways
01:09:25 Subscription and Support Options

Links:
Human faces and mortality predictions: https://bit.ly/3rA0tgd
Biological age prediction in human skin: https://bit.ly/3LdDZcO
Senescent cells and lifespan in mice: https://go.nature.com/3HFO9Rh
Nail growth and aging: https://bit.ly/34tnSYb
Autophagy is a major regulator of aging: https://bit.ly/3uHh2Jr
Hyaluronan and cancer resistance: https://go.nature.com/3HHoyHK
Topical tretinoin and hair growth: https://bit.ly/3GCF0rl
Dihydrotestosterone levels correlate with mortality: https://bit.ly/3GBFFJJ
Eunuchs are especially long-lived: https://bit.ly/3ukL1GU
Human hair greying is linked to life stress: https://bit.ly/3J5adVU
Grey hair reversal in mice: https://bit.ly/3Li9F0J

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.